Pesquisa | BVS Doenças Infecciosas e Parasitárias

1.

Decaf or regular? Energizing the caffeine receptor.

Stahl, Edward L; Bohn, Laura M.

Cell ; 184(7): 1659-1660, 2021 04 01.

Artigo em Inglês | MEDLINE | ID: mdl-33798438

2.

Activation and Signaling Mechanism Revealed by Cannabinoid Receptor-G_i Complex Structures.

Hua, Tian; Li, Xiaoting; Wu, Lijie; Iliopoulos-Tsoutsouvas, Christos; Wang, Yuxia; Wu, Meng; Shen, Ling; Brust, Christina A; Nikas, Spyros P; Song, Feng; Song, Xiyong; Yuan, Shuguang; Sun, Qianqian; Wu, Yiran; Jiang, Shan; Grim, Travis W; Benchama, Othman; Stahl, Edward L; Zvonok, Nikolai; Zhao, Suwen; Bohn, Laura M; Makriyannis, Alexandros; Liu, Zhi-Jie.

Cell ; 180(4): 655-665.e18, 2020 02 20.

Artigo em Inglês | MEDLINE | ID: mdl-32004463

3.

Crystal Structure of the Human Cannabinoid Receptor CB2.

Li, Xiaoting; Hua, Tian; Vemuri, Kiran; Ho, Jo-Hao; Wu, Yiran; Wu, Lijie; Popov, Petr; Benchama, Othman; Zvonok, Nikolai; Locke, K'ara; Qu, Lu; Han, Gye Won; Iyer, Malliga R; Cinar, Resat; Coffey, Nathan J; Wang, Jingjing; Wu, Meng; Katritch, Vsevolod; Zhao, Suwen; Kunos, George; Bohn, Laura M; Makriyannis, Alexandros; Stevens, Raymond C; Liu, Zhi-Jie.

Cell ; 176(3): 459-467.e13, 2019 01 24.

Artigo em Inglês | MEDLINE | ID: mdl-30639103

4.

Bias Factor and Therapeutic Window Correlate to Predict Safer Opioid Analgesics.

Schmid, Cullen L; Kennedy, Nicole M; Ross, Nicolette C; Lovell, Kimberly M; Yue, Zhizhou; Morgenweck, Jenny; Cameron, Michael D; Bannister, Thomas D; Bohn, Laura M.

Cell ; 171(5): 1165-1175.e13, 2017 Nov 16.

Artigo em Inglês | MEDLINE | ID: mdl-29149605

5.

Crystal Structure of the Human Cannabinoid Receptor CB₁.

Hua, Tian; Vemuri, Kiran; Pu, Mengchen; Qu, Lu; Han, Gye Won; Wu, Yiran; Zhao, Suwen; Shui, Wenqing; Li, Shanshan; Korde, Anisha; Laprairie, Robert B; Stahl, Edward L; Ho, Jo-Hao; Zvonok, Nikolai; Zhou, Han; Kufareva, Irina; Wu, Beili; Zhao, Qiang; Hanson, Michael A; Bohn, Laura M; Makriyannis, Alexandros; Stevens, Raymond C; Liu, Zhi-Jie.

Cell ; 167(3): 750-762.e14, 2016 Oct 20.

Artigo em Inglês | MEDLINE | ID: mdl-27768894

6.

G protein signaling-biased mu opioid receptor agonists that produce sustained G protein activation are noncompetitive agonists.

Stahl, Edward L; Schmid, Cullen L; Acevedo-Canabal, Agnes; Read, Cai; Grim, Travis W; Kennedy, Nicole M; Bannister, Thomas D; Bohn, Laura M.

Proc Natl Acad Sci U S A ; 118(48)2021 11 30.

Artigo em Inglês | MEDLINE | ID: mdl-34819362

7.

Structural and functional insights into the G protein-coupled receptors: CB1 and CB2.

Brust, Christina A; Swanson, Matthew A; Bohn, Laura M.

Biochem Soc Trans ; 51(4): 1533-1543, 2023 08 31.

Artigo em Inglês | MEDLINE | ID: mdl-37646476

8.

Crystal structures of agonist-bound human cannabinoid receptor CB₁.

Hua, Tian; Vemuri, Kiran; Nikas, Spyros P; Laprairie, Robert B; Wu, Yiran; Qu, Lu; Pu, Mengchen; Korde, Anisha; Jiang, Shan; Ho, Jo-Hao; Han, Gye Won; Ding, Kang; Li, Xuanxuan; Liu, Haiguang; Hanson, Michael A; Zhao, Suwen; Bohn, Laura M; Makriyannis, Alexandros; Stevens, Raymond C; Liu, Zhi-Jie.

Nature ; 547(7664): 468-471, 2017 07 27.

Artigo em Inglês | MEDLINE | ID: mdl-28678776

9.

Low Intrinsic Efficacy Alone Cannot Explain the Improved Side Effect Profiles of New Opioid Agonists.

Stahl, Edward L; Bohn, Laura M.

Biochemistry ; 61(18): 1923-1935, 2022 09 20.

Artigo em Inglês | MEDLINE | ID: mdl-34468132

10.

A Genetically Encoded F-19 NMR Probe Reveals the Allosteric Modulation Mechanism of Cannabinoid Receptor 1.

Wang, Xiaoyan; Liu, Dongsheng; Shen, Ling; Li, Fahui; Li, Yongze; Yang, Lingyun; Xu, Tiandan; Tao, Houchao; Yao, Deqiang; Wu, Lijie; Hirata, Kunio; Bohn, Laura M; Makriyannis, Alexandros; Liu, Xiaohong; Hua, Tian; Liu, Zhi-Jie; Wang, Jiangyun.

J Am Chem Soc ; 143(40): 16320-16325, 2021 10 13.

Artigo em Inglês | MEDLINE | ID: mdl-34596399

11.

Arrestin recruitment to dopamine D2 receptor mediates locomotion but not incentive motivation.

Donthamsetti, Prashant; Gallo, Eduardo F; Buck, David C; Stahl, Edward L; Zhu, Ying; Lane, J Robert; Bohn, Laura M; Neve, Kim A; Kellendonk, Christoph; Javitch, Jonathan A.

Mol Psychiatry ; 25(9): 2086-2100, 2020 09.

Artigo em Inglês | MEDLINE | ID: mdl-30120413

12.

Some effects of putative G-protein biased mu-opioid receptor agonists in male rhesus monkeys.

Cornelissen, Jeremy C; Blough, Bruce E; Bohn, Laura M; Negus, S Stevens; Banks, Matthew L.

Behav Pharmacol ; 32(5): 453-458, 2021 08 01.

Artigo em Inglês | MEDLINE | ID: mdl-33883450

13.

Probing the CB₁ Cannabinoid Receptor Binding Pocket with AM6538, a High-Affinity Irreversible Antagonist.

Laprairie, Robert B; Vemuri, Kiran; Stahl, Edward L; Korde, Anisha; Ho, Jo-Hao; Grim, Travis W; Hua, Tian; Wu, Yiran; Stevens, Raymond C; Liu, Zhi-Jie; Makriyannis, Alexandros; Bohn, Laura M.

Mol Pharmacol ; 96(5): 619-628, 2019 11.

Artigo em Inglês | MEDLINE | ID: mdl-31515283

14.

O6C-20-nor-salvinorin A is a stable and potent KOR agonist.

Hirasawa, Shun; Cho, Min; Brust, Tarsis F; Roach, Jeremy J; Bohn, Laura M; Shenvi, Ryan A.

Bioorg Med Chem Lett ; 28(16): 2770-2772, 2018 09 01.

Artigo em Inglês | MEDLINE | ID: mdl-29426768

15.

Stolonidiol: Synthesis, Target Identification, and Mechanism for Choline Acetyltransferase Activation.

Mason, Jeremy W; Schmid, Cullen L; Bohn, Laura M; Roush, William R.

J Am Chem Soc ; 139(16): 5865-5869, 2017 04 26.

Artigo em Inglês | MEDLINE | ID: mdl-28414442

16.

Synthesis of Kappa Opioid Antagonists Based On Pyrrolo[1,2-α]quinoxalinones Using an N-Arylation/Condensation/Oxidation Reaction Sequence.

Scarry, Sarah M; Lovell, Kimberly M; Frankowski, Kevin J; Bohn, Laura M; Aubé, Jeffrey.

J Org Chem ; 81(21): 10538-10550, 2016 11 04.

Artigo em Inglês | MEDLINE | ID: mdl-27399050

17.

Biased agonism: An emerging paradigm in GPCR drug discovery.

Rankovic, Zoran; Brust, Tarsis F; Bohn, Laura M.

Bioorg Med Chem Lett ; 26(2): 241-250, 2016 Jan 15.

Artigo em Inglês | MEDLINE | ID: mdl-26707396

18.

Fulfilling the Promise of "Biased" G Protein-Coupled Receptor Agonism.

Luttrell, Louis M; Maudsley, Stuart; Bohn, Laura M.

Mol Pharmacol ; 88(3): 579-88, 2015 Sep.

Artigo em Inglês | MEDLINE | ID: mdl-26134495

19.

A novel method for analyzing extremely biased agonism at G protein-coupled receptors.

Stahl, Edward L; Zhou, Lei; Ehlert, Frederick J; Bohn, Laura M.

Mol Pharmacol ; 87(5): 866-77, 2015 May.

Artigo em Inglês | MEDLINE | ID: mdl-25680753

20.

Exploring the Biology of G Protein-Coupled Receptors from In Vitro to In Vivo.

Bohn, Laura M; Lohse, Martin J; Nitabach, Michael N; Taghert, Paul H; Smit, Martine J.

Mol Pharmacol ; 88(3): 534-5, 2015 Sep.

Artigo em Inglês | MEDLINE | ID: mdl-26162863

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